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Chemoattractant activity of selected pyridazinones in human neutrophils
| Compd | EC50 (μM)[a] |
|---|---|
| 4a | 0.27 ± 0.06 |
| 4b | 0.51 ± 0.11 |
| 7b | 2.1 ± 0.53 |
The data are presented as the mean ± SD of three independent experiments with cells from different donors, in which median effective concentration values (EC50) were determined by nonlinear regression analysis of the concentration-response curves (5-6 points) generated using GraphPad Prism 5 with 95% confidential interval (p < 0.05).
