HYP content as measured in the microsphere-based scaffolds over weeks 0, 3 and 6. (A) Total HYP content in micrograms per construct. (B) Normalized HYP content in micrograms per microgram of DNA. All values are expressed as the average + standard deviation (n = 6). The TCP/HAp groups had significantly higher normalized HYP content than the BLANK and BMP controls at week 6. *significant difference from the BLANK negative control group at same time point, @significant difference from the BMP positive control group at same time point, &significant difference from the TCP/HAp 1:1 group at same time point, #significant change from its value at week 0, and %significant change from its value at week 3 (p < 0.05).