Table 4.

Proteins, biological processes, molecular functions, and components of the significantly regulated proteins found in the present study (from http://www.ebi.ac.uk/QuickGO/GProtein?ac=P12075, http://www.genecards.org/, and http://www.uniprot.org/uniprot/P02761).

Protein	Biological process	Molecular function	Related pathways	General comment	Component	Alias
COX5B_RAT	Hydrogen ion transmembrane transport Respiratory gaseous exchange	Cytochrome c oxidase activity protein binding metal ion binding	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Metabolism Oxidative phosphorylation Gene expression Alzheimer's disease Respiratory electron transport TP53 regulates metabolic genes	Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multisubunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.	Mitochondrion, mitochondrial envelope, mitochondrial inner membrane, extracellular exosome	Cytochrome c oxidase polypeptide VB, mitochondrial Cytochrome c oxidase Polypeptide Vb Cytochrome c oxidase Subunit Vb COXVB
MUP	Transport/transporter activity	Small molecule binding		Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviours, such as aggression, mating, pup-suckling, territory establishment, and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.	Extracellular region
Myh6	ATP metabolic process	ATP binding microfilament motor activity actin binding protein binding	Cell adhesion, integrin-mediated cell adhesion, and migration Cytoskeleton remodeling regulation of actin cytoskeleton by Rho GTPases	Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4 kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. MYH6 (Myosin, Heavy Chain 6, Cardiac Muscle, Alpha) is a Protein coding gene. Diseases associated with MYH6 include myh6-related dilated cardiomyopathy and myh6-related familial hypertrophic cardiomyopathy. Among its related pathways are RhoGDI Pathway and PAK Pathway. GO annotations related to this gene include protein kinase binding and ATPase activity. An important paralog of this gene is MYH4.	Cytoplasm and myosin complex	Myosin, Heavy Chain 6, Cardiac Muscle, Alpha Myosin, Heavy Polypeptide 6, Cardiac Muscle, Alpha (cardiomyopathy, Hypertrophic 1) Myosin Heavy Chain, Cardiac Muscle Alpha Isoform Myosin Heavy Chain 6 MyHC-Alpha
Myh7	ATP metabolic process	ATP binding microfilament motor activity actin binding protein binding		Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.	Cytoplasm and myosin complex	Myosin, Heavy Chain 7, Cardiac Muscle, Beta Myosin, Heavy Polypeptide 7, Cardiac Muscle, Beta Myosin Heavy Chain Slow Isoform MYHCB