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. 2017 Jan 26;2017:7834035. doi: 10.1155/2017/7834035

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Copyright © 2017 Xiaoqing Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Combined effect of IL-18 rs5744247 and rs1946518 and CYP3A5 rs776746 polymorphisms on tacrolimus concentration/dose (C/D) ratios in lung transplant patients at week 1 (a), week 2 (b), week 3 (c), and week 4 (d) following transplantation. The lung transplant recipients were divided into 4 groups according to the number of IL-18 alleles associated with fast tacrolimus metabolism and CYP3A5 genotype: Group 1 (CYP3A5 expresser and the number of alleles greater than or equal to 3); Group 2 (CYP3A5 expressers and the number of alleles less than or equal to 2); Group 3 (CYP3A5 nonexpresser and the number of alleles greater than or equal to 3); Group 4 (CYP3A5 nonexpressers and the number of alleles less than or equal to 2). Among the patients with CYP3A5 expression genotype, the impact of IL-18 polymorphisms on tacrolimus C/D ratios was significant.