. 2017 Jan 26;2017:7834035. doi: 10.1155/2017/7834035

Table 2.

Comparison of tacrolimus concentration/dose ratios in different groups of CYP3A5, IL-18, and IL-10 polymorphisms at different times after drug initiation.

Gene	Locus	Genotype	Week 1		Week 2		Week 3		Week 4
Gene	Locus	Genotype	C/D ratio	P	C/D ratio	P	C/D ratio	P	C/D ratio	P
CYP3A5	rs776746	GG	243.9 ± 244.2	0.005	218.2 ± 211.9	0.008	194.0 ± 212.2	0.003	156.8 ± 188.6	<0.001
CYP3A5	rs776746	AG+AA	96.8 ± 145.6	0.005	97.0 ± 143.0	0.008	79.5 ± 130.6	0.003	80.6 ± 59.2	<0.001

IL-18	rs5744247	GG+CG	202.3 ± 241.1	0.002	204.6 ± 181.0	0.004	192.2 ± 186.7	0.005	115.7 ± 132.4	0.026
IL-18	rs5744247	CC	92.4 ± 144.2	0.002	79.2 ± 135.5	0.004	74.8 ± 133.8	0.005	73.9 ± 110.3	0.026

IL-18	rs1946518	CC	269.5 ± 239.0	0.007	224.0 ± 192.4	0.018	197.7 ± 226.3	0.019	151.0 ± 193.5	0.079
		CA	191.6 ± 192.2		159.3 ± 194.6		158.7 ± 158.6		108.1 ± 96.8
		AA	76.6 ± 108.8		79.2 ± 86.3		65.9 ± 84.4		73.9 ± 110.3

IL-10	rs1800896	AA	193.9 ± 224.8	0.027	176.8 ± 205.1	0.034	170.8 ± 186.7	0.24	104.8 ± 125.9	0.24
IL-10	rs1800896	AG	77.2 ± 66.4	0.027	74.1 ± 32.2	0.034	77.8 ± 41.6	0.24	85.6 ± 44.9	0.24

IL-10	rs1800872	AA	191.6 ± 232.3	0.985	167.5 ± 222.7	0.863	158.7 ± 228.8	0.909	98.8 ± 156.3	0.605
IL-10	rs1800872	CA+CC	165.8 ± 209.1	0.985	137.8 ± 171.2	0.863	133.8 ± 148.0	0.909	103.0 ± 86.3	0.605

IL-10	rs3021097	CC+TC	159.2 ± 211.7	1.000	138.7 ± 179.2	0.909	133.9 ± 154.5	0.879	97.8 ± 86.8	0.634
IL-10	rs3021097	TT	184.3 ± 211.5	1.000	145.5 ± 217.2	0.909	134.6 ± 224.2	0.879	100.0 ± 142.5	0.634