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. 2017 Feb 9;7:41772. doi: 10.1038/srep41772

Table 1. Selected up-regulated genes of macrophages phagocytizing iRBC as determined by DNA microarray analysis and qRT-PCR.

Gene Genbank Accession number Fold changeaa
Microarray qRT-PCRb qRT-PCRc
SMTNL2 NM_198501 4.613 7.20 ± 8.59 14.57 ± 11.72
DEFB130 NM_001037804 4.569 4.49 ± 3.93 3.45 ± 1.75
RIT2 NM_002930 4.543 5.74 ± 2.53 4.11 ± 6.60
SYTL4 NM_080737 4.459 5.87 ± 3.77 6.20 ± 4.60
PRSS41 NM_001135086 3.912 1.71 ± 0.85 3.44 ± 3.06
GRP NM_002091 2.726 4.62 ± 4.95 3.38 ± 1.80
ADAM19 NM_033274 2.209 1.54 ± 1.30 1.72 ± 0.73

aFold change indicates the mean expression level of the gene in macrophages co-cultured with iRBCs normalized to that in macrophages co-cultured with RBCs.

bResults of qRT-PCR are from the same samples used for the microarray. Results represent the mean fold change ± SEM of three independent experiments.

cResults of qRT-PCR are from pooled data of samples collected from three individual donors. Results represent the mean fold change ± SEM (n = 3).