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. 2017 Feb 9;7:41712. doi: 10.1038/srep41712

Figure 7. BBR suppresses tumor growth and inhibits mitochondrial activity.

Figure 7

HepG2 xenograft model was established by subcutaneously implanting HepG2 cells into CD1-Nude mice. And the mice were given vehicle or BBR at the indicated doses for 4 weeks. N = 6. (A) Final tumor weight at the end of experiment. Mean ± SEM; *p < 0.05, n = 6. (B) ATP, ADP and AMP concentration and energy charge (EC) of tumor. Mean ± SEM; *p < 0.05, **p < 0.01, n = 6. (C) The mRNA expression of enzymes in glycolysis. Mean ± SEM; *p < 0.05, ***p < 0.001, n = 3. (D) mRNA expression of TCA cycle enzymes. Mean ± SEM; *p < 0.05, n = 3. (E) mtDNA copy number of tumor cell. Mean ± SEM; **p < 0.01, n = 3. (F) mRNA expression of factors involved in mitochondrial fusion. Mean ± SEM; *p < 0.05, n = 3. (G) mRNA expression of factors involved in mitochondrial. Mean ± SEM; *p < 0.05, n = 3. (H) mRNA expression of factors involved in mtDNA replication. Mean ± SEM; *p < 0.05, n = 3.