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. 2017 Feb 9;7:42304. doi: 10.1038/srep42304

Figure 7. Analgesic effects of pregabalin in EAE and EAEnp mice.

Figure 7

Mechanical sensitivity to a 0.02-g von Frey filament was evaluated in mice at 41 to 50 days post-immunization. (a) Dose-dependent effect of pregabalin in EAE mice (30 μg/kg N = 5, 100 μg/kg N = 5, 1 mg/kg N = 5, i.p.). Statistics were analyzed by two-way ANOVA (EAE: Interaction: F(10,60) = 3.264; Time: F(5,60) = 14.77; Drug dose: F(2,12) = 12.35). (b) Dose-dependent effect of pregabalin in EAEnp mice (30 μg/kg N = 5, 100 μg/kg N = 6, 1 mg/kg N = 6, i.p.). Statistics were analyzed by two-way ANOVA (EAEnp:Interaction: F(10,70) = 4.121; Time: F(5,70) = 17.53; Drug dose: F(2,14) = 5.176). Post-Bonferroni analysis presented in the figure, *P < 0.05, 30 μg/kg vs. 100 μg/kg; #P < 0.05, 30 μg/kg vs. 1 mg/kg.