Table 1.
Subject demographic and baseline characteristics
| Parameter |
Usual care/NB + CLI (N = 89) |
NB + CLI (N = 153) |
|---|---|---|
| Age (y), mean (SD) | 47.0 (9.98) | 46.1 (9.66) |
| Sex, (% female) | 86.5 | 81.7 |
| Race (%) | ||
| White | 71.9 | 81.0 |
| Black or African American | 27.0 | 18.3 |
| Asian | 0.0 | 0.7 |
| American Indian or Alaska Native | 1.1 | 0.0 |
| Ethnicity (%) | ||
| Hispanic or Latino | 5.6 | 2.6 |
| Not Hispanic or Latino | 94.4 | 97.4 |
| Weight (kg), mean (SD) | 100.2 (16.58) | 101.4 (15.09) |
| BMI (kg/m2), mean (SD) | 36.26 (4.36) | 36.33 (4.20) |
| BMI category (%) | ||
| <30 kg/m2 | 5.6 | 2.0 |
| <35 kg/m2 | 46.1 | 45.8 |
| ≥35 to <40 kg/m2 | 31.5 | 32.0 |
| ≥40 kg/m2 | 22.5 | 22.2 |
| Waist circumference (cm), mean (SD) | 111.9 (11.91) | 112.2 (11.23) |
| Triglycerides (mg/dL), mean (SD) |
n = 86 114.8 (54.40) |
n = 147 131.0 (70.09) |
| LDL cholesterol (mg/dL), mean (SD) |
n = 84 118.0 (26.17) |
n = 147 115.5 (27.63) |
| HDL cholesterol (mg/dL), mean (SD) |
n = 84 50.4 (12.75) |
n = 147 50.7 (11.38) |
| Glucose (mg/dL), mean (SD) |
n = 86 92.4 (11.46) |
n = 147 89.7 (10.56) |
| Insulin (uIU/mL), mean (SD) |
n = 84 17.3 (10.68) |
n = 147 19.5 (19.65) |
| HOMA‐IR, mean (SD) |
n = 84 4.07 (2.96) |
n = 147 4.41 (5.01) |
| Systolic blood pressure (mm Hg), mean (SD) | 120.6 (11.41) | 123.7 (9.51) |
| Diastolic blood pressure (mm Hg), mean (SD) | 78.8 (7.60) | 80.4 (7.26) |
| Heart rate (bpm), mean (SD) | 69.8 (8.68) | 70.9 (8.66) |
BMI, body mass index; CLI, comprehensive lifestyle intervention; HDL, high‐density lipoprotein; HOMA‐IR, homeostasis model assessment of insulin resistance; LDL, low‐density lipoprotein; NB, naltrexone/bupropion; SD, standard deviation.