Table 2.
Unadjusted and adjusted hazard ratios for total mortality by time since randomization
| EVAR‐1 (n = 1252) | DREAM (n = 351) | OVER (n = 881) | ACE (n = 299) | Pooled (n = 2783) | |
|---|---|---|---|---|---|
| Proportion of patients who died* | |||||
| All patients | |||||
| EVAR | 260 of 626 (7·5) | 58 of 173 (6·2) | 146 of 444 (6·3) | 17 of 150 (4·1) | 481 of 1393 (6·7) |
| Open repair | 264 of 626 (7·7) | 60 of 178 (6·2) | 146 of 437 (6·4) | 12 of 149 (2·9) | 482 of 1390 (6·8) |
| Time since randomization | |||||
| 0–6 months | |||||
| EVAR | 26 of 626 (8·5) | 6 of 173 (7·1) | 11 of 444 (5·0) | 3 of 150 (4·6) | 46 of 1393 (6·7) |
| Open repair | 45 of 626 (15·0) | 10 of 178 (11·6) | 17 of 437 (8·0) | 1 of 149 (1·4) | 73 of 1390 (10·9) |
| 6 months to 4 years | |||||
| EVAR | 125 of 599 (6·7) | 33 of 167 (6·2) | 73 of 433 (5·2) | 13 of 146 (3·8) | 244 of 1345 (5·9) |
| Open repair | 116 of 581 (6·3) | 25 of 168 (4·6) | 78 of 420 (5·9) | 10 of 146 (3·0) | 229 of 1315 (5·7) |
| > 4 years | |||||
| EVAR | 109 of 472 (8·4) | 19 of 134 (6·0) | 62 of 348 (8·6) | 1 of 33 (17·7) | 191 of 987 (8·2) |
| Open repair | 103 of 461 (7·9) | 25 of 143 (7·4) | 51 of 331 (7·0) | 1 of 23 (17·5) | 180 of 958 (7·6) |
| Unadjusted hazard ratio† | |||||
| All patients | 0·98 | 1·00 | 0·97 | 1·52 | 0·99 |
| (0·82, 1·16) | (0·70, 1·44) | (0·77, 1·23) | (0·71, 3·25) | (0·87, 1·13) | |
| Time since randomization | |||||
| 0–6 months | 0·57 | 0·60 | 0·63 | 2·97 | 0·61 |
| (0·35, 0·92) | (0·22, 1·66) | (0·29, 1·34) | (0·31, 28·60) | (0·42, 0·89)¶ | |
| 6 months to 4 years | 1·06 | 1·36 | 0·89 | 1·25 | 1·04 |
| (0·82, 1·37) | (0·81, 2·28) | (0·65, 1·23) | (0·55, 2·86) | (0·87, 1·25) | |
| > 4 years | 1·06 | 0·81 | 1·22 | – | 1·07 |
| (0·81, 1·39) | (0·45, 1·47) | (0·85, 1·77) | (0·88, 1·32) | ||
| No. of patients in adjusted analysis | 1246 | 339 | 881 | 281 | 2747 |
| Adjusted hazard ratio† ‡ | |||||
| All patients | 1·00 | 0·88 | 1·04 | 1·43 | 1·01 |
| (0·84, 1·19) | (0·61, 1·27) | (0·82, 1·31) | (0·63, 3·22) | (0·89, 1·14) | |
| Time since randomization | |||||
| 0–6 months | 0·58 | 0·42 | 0·62 | –§ | 0·57 |
| (0·36, 0·95) | (0·14, 1·25) | (0·29, 1·33) | (0·39, 0·84)¶ | ||
| 6 months to 4 years | 1·08 | 1·15 | 0·94 | 1·14 | 1·05 |
| (0·84, 1·40) | (0·68, 1·95) | (0·69, 1·30) | (0·49, 2·68) | (0·87, 1·26) | |
| > 4 years | 1·11 | 0·79 | 1·30 | –§ | 1·12 |
| (0·85, 1·46) | (0·43, 1·44) | (0·89, 1·90) | (0·91, 1·38) | ||
Value in parentheses are *rate per 100 person‐years and
†
95 per cent confidence intervals.
‡
Adjusted for age, sex, maximum aneurysm diameter and log creatinine.
§
Too few events to estimate a hazard ratio. EVAR, endovascular aneurysm repair.
¶
P < 0·050.