Figure 4.

Drug development pipeline highlighting the phases developed by the FIBROTARGETS consortium (modified from Phrma.com). The activities developed by the consortium cover the first steps of the drug discovery strategy; high throughput screening (HTS), hit to lead phase, and lead optimization. By the end of the project, we aim to have identified a set of promising candidates for further evaluation. ADME, absorption, distribution, metabolism, and excretion; FDA, Food and Drug Administration; IC₅₀, half‐maximal inhibitory concentration; HCS, high content screening; IND, investigational new drug; MFG, manufacturing; NDA, new drug application; PD, pharmacodynamics; PK, pharmacokinetics; POC, proof of concept.