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Schematic representation of the chemically induced scaffold system consisting of a 14‐3‐3 dimer and a recombinant fusion protein of caspase‐9 fused to a CT52 domain (C9‐CT52). Upon addition of the small‐molecule stabiliser fusicoccin (FC), two C9‐CT52 units assemble on the scaffold, and this leads to caspase‐9 activation through dimerisation and a concomitant increase in enzymatic activity.
