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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Fitoterapia. 2016 Apr 20;111:109–123. doi: 10.1016/j.fitote.2016.04.013

Fig. 6.

Fig. 6

Lobinaline (LBNA) activates nicAchRs and inhibits the DAT. Data expressed as the mean ± S.E.M. A) NIC (10 μM) and LBNA (1 mM) significantly increase 45Ca2+ entry in SH-SY5Y cells. LBNA significantly attenuates NIC-induced 45Ca2+ entry, and MEC (1 μM) pretreatment completely abolishes lobinaline-induced 45Ca2+ entry. ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. vehicle, student’s one-tailed t-test. # p < 0.05 vs. cells treated with NIC alone, student’s one-tailed t-test. n = 3 – 4. B.) Lobinaline dose-dependently inhibits the DAT (IC50 = 11.95 μM). n = 3 – 4.