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. Author manuscript; available in PMC: 2017 Jun 1.

Published in final edited form as: Fitoterapia. 2016 Apr 20;111:109–123. doi: 10.1016/j.fitote.2016.04.013

Table 2.

NicAchR selectivity of lobinaline, lobeline, and nicotine at α₄β₂- and α₇-nicAchRs

	K_i μM		NicAchR Selectivity

Compound	α₄β₂-nicAchR	α₇-nicAchR	(-fold difference)⁵	DDR value
Lobinaline	1.066	67.54	63	1.32
Lobeline³	0.004	6.26	1565	6.27⁶
Nicotine⁴	0.00096	1.448	1508	13.00⁶

³

Ki’s previously reported by Hojahmat et al. (2010)

⁴

Ki’s previously reported by Rueter et al. (2006)

⁵

Selectivity based on comparison of K_i’s

⁶

DDR values previously reported by Littleton et al. (2005)