Table 2. Genotypic analysis of IL-37 SNP rs3811047 with CAD in the GeneID Chinese Han population under three genetic models.
| Cohort (N, Case/Control) | Genotype |
Model | Pobs | OR (95% CI) | Padj | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| Cases (N) | Controls (N) | |||||||
| GeneID Central (1,503/2,040) | AA | 77 | 60 | Additive | 1.31 × 10−3 | n.a | 0.46 | 1.06 (0.91–1.24) |
| AG | 402 | 607 | Dominant | 0.98 | 1.00 (0.87–1.16) | 0.64 | 0.98 (0.89–1.07) | |
| GG | 984 | 1373 | Recessive | 4.72 × 10–4 | 1.83 (1.30–2.59) | 1.23 × 10−3 | 1.45 (1.16–1.83) | |
| GeneID Northern (998/1,076) | AA | 46 | 20 | Additive | 5.80 × 10−5 | n.a | 0.02 | 1.27 (1.04–1.55) |
| AG | 349 | 310 | Dominant | 3.49 × 10−4 | 1.39 (1.16–1.66) | 0.11 | 1.10 (0.98–1.24) | |
| GG | 643 | 746 | Recessive | 6.72 × 10−4 | 2.45 (1.44–4.17) | 5.51 × 10−3 | 1.56 (1.14–2.13) | |
| GeneID Combined (2,501/3,116) | AA | 123 | 80 | Additive | 9.21 × 10−6 | n.a | 1.28 × 10−2 | 1.16 (1.03–1.30) |
| AG | 751 | 917 | Dominant | 1.97 × 10−2 | 1.14 (1.02–1.28) | 0.24 | 1.04 (0.97–1.11) | |
| GG | 1627 | 2119 | Recessive | 2.72 × 10−6 | 1.96 (1. 47–2.61) | 9.70 × 10−6 | 1.47 (1.24–1.74) | |
Pobs, P value from Chi square tests with 2 × 3 contingency tables without adjustment for covariates;
Padj, P value adjusted by covariates of sex, age, hypertension, T2D and lipid concentrations by multiple logistic regression analysis;
OR, odds ratio;
95% CI, 95% confidence interval;
Additive model = AA/AG/GG; Dominant model = AA + AG/GG; Recessive model = AA/AG + GG.