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. 2017 Feb 9;7:42079. doi: 10.1038/srep42079

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The distribution of relative gene expression levels (fold change values in log2 scale) between Gfi1^Cre/+ (Het) and Gfi1^+/+ (WT) samples was calculated for sets of HC-enriched transcripts and compared with the fold change of remaining genes in the dataset (background). HC-enriched sets of genes (consisting of genes that showed at least 3-fold elevated expression in HCs compared to non-HCs from either the (A) Elkon et al. dataset (871 genes), (B) Cai et al. dataset (1,817 genes) or (C) defined by the overlap between these two datasets (521 genes)), exhibited statistically significant decreased expression in Gfi1^Cre/+ P8 cochlea compared to their wild-type control (p-values = (A) 1.67E-15, (B) 6.03E-11, (C) 1.17E-14, calculated using Wilcoxon’s test).