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. 2017 Feb 9;7:42147. doi: 10.1038/srep42147

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Antibody levels against purified antigens were analyzed by ELISA in 200 fold diluted sera from mice (A) and NHP (B,C). Autoantibodies level were analyzed in naïve (n = 8) or MA-EBOV challenged mice (2 or 3 weeks post inoculation) (n = 16). Challenged mice were separated based on humoral response against GP. (A) Autoantibody levels were also monitored in NHPs (n = 5) before (open circles), 21 days post VSV-GP immunization (grey squares) and 26 days post EBOV challenge (filled triangles) (B). Autoantibody levels were in NHP before (open circle) and 28 days post EBOV challenge (filled triangles) in NHPs treated with ZMapp starting 4 or 5 days after challenge are also illustrated(n = 12) (C). Samples were analyzed in triplicate.