| T2R38 |
Human upper respiratory system |
T2R38 genotype is correlated with susceptibility, severity, and prognosis of chronic rhinosinusitis, as well as biofilm formation in chronic rhinosinusitis patients |
Lee et al., 2012; Lee and Cohen, 2013; Adappa et al., 2014, 2016a,b,c
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Human colorectal cancer |
T2R38 nonfunctional group has an increased risk of colorectal cancer in a population of Caucasian origin |
Carrai et al., 2011 |
|
Human gingiva |
T2R38 genotype is associated with gingival innate immunity and the risk of dental caries |
Wendell et al., 2010; Gil et al., 2015
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Human colonic mucosa |
Increased number of T2R38 immunoreactive cells in overweight and obese subjects |
Latorre et al., 2016 |
| T2R19 |
Blood glucose |
T2R19 haplotype is associated with altered glucose and insulin homeostasis |
Dotson et al., 2008 |
| T2R50 |
Human heart |
T2R50 SNPs (ID rs1376251) have a strong association with cardiovascular disease |
Shiffman et al., 2008 |
| T2R42 |
Thyroid |
Thyroid-expressed T2R42 SNP (SNP type L196F) is associated with differences in circulating levels of thyroid hormones |
Clark et al., 2015 |
| T2R16 |
Longevity |
An upstream position polymorphism of T2R16 is significantly associated with longevity |
Campa et al., 2012 |
| T2Rs |
Human leukocytes |
10 T2Rs are up-regulated in leukocytes in severe asthma patients |
Orsmark-Pietras et al., 2013 |
| T2Rs |
Human Parkinson’s disease patients’ brains |
T2R5 and T2R50 are decreased, whereas T2R10 and T2R13 are augmented at both premotor and parkinsonian stages in the frontal cortex area |
Garcia-Esparcia et al., 2013 |
|
Human schizophrenia patients’ brains |
T2R4, T2R5, T2R14, and T2R50 are down-regulated in the dorsolateral prefrontal cortex |
Ansoleaga et al., 2015 |
| T2R4 |
Human breast cancer |
T2R4 is down-regulated in breast cancer cells |
Singh et al., 2014 |
| T2R105 |
Mouse testes |
Depletion of T2R105 results in smaller testes and leads to male infertility |
Li and Zhou, 2012 |
|
Mouse glomerulus and renal tubule |
Ablation of T2R105-positive cells causes an increase in the size of the glomerulus and renal tubule and a lower cell density in the glomerulus |
Liu et al., 2015 |
| T2R126, T2R135, and T2R143 |
Mouse heart |
Starvation increases the expression of these T2Rs by two- to threefold |
Foster et al., 2013 |
