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. 2017 Feb;149(2):277–293. doi: 10.1085/jgp.201611721

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© 2017 Yan et al.

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Figure 1. — LQT3 mutations in the IQ domain increase the persistent Na⁺ current amplitude. (A) Exemplar traces of the pseudo-WT Na_V1.5^TTX-S and Q1909R (magnified region on the right). Y axis of scale bars represents the percentage of persistent current amplitude normalized to the peak Na⁺ current. The inset shows I-V plots of peak current amplitude for Na_V1.5^TTX-S and Q1909R, demonstrating no significant difference in peak current amplitude between Na_V1.5^TTX-S and Q1909R. (B) Magnified region of exemplar traces showing persistent Na⁺ current for the LQT3 mutations in the CaM C-lobe–binding site and the L1917K. (C) Quantification of persistent Na⁺ current (as % peak of current). The white number in each bar indicates the number of cells, n. Data are presented as mean ± SEM. **, P < 0.01.