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. 2017 Feb 8;15:26. doi: 10.1186/s12967-017-1122-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — An example of three CpG sites with pairwise stable RMOs in normal samples (a) and reversal RMOs in cancer samples (b). Four paired cancer-normal samples from GSE32866 were used to show this biological phenomenon. Red, blue and green points represent cg15778232, cg26521404 and cg03606258 CpG sites, respectively