Table 4.
Relationship between IL-8/GDF-15 and risk of 28-day mortality in a subgroup of patients with AECOPD
| IL-8 and GDF-15 on admission vs 28 days follow-up death – AECOPD subgroup | ||||
|---|---|---|---|---|
| IL-8 | GDF-15 | |||
| Continuous analysis (per SD increment) | P-value | Continuous analysis (per SD increment) | P-value | |
| N/N eventsb | 34/11 | 34/11 | ||
| HR (95% CI) (age and gender adjusted) | 4.16 (1.84–9.39) | 0.001 | 3.10 (1.30–7.40) | 0.011 |
| HR (95% CI) (age, gender and CRP adjusted)a | 4.34 (2.05–9.19) | <0.001 | 3.28 (1.56–6.88) | 0.002 |
AECOPD acute exacerbation of COPD, SD standard deviation, HR hazard ratio, CI confidence interval, CRP C-reactive protein
aBackward elimination model
bdeath within 28 days from admission