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. 2017 Feb 8;17:28. doi: 10.1186/s12883-016-0772-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — PBMC-derived ACh levels correlate positively with MG severity. a Histogram shows that ACh concentrations per million cells increased along with MG severity according to the MGFA clinical classification (n = 50 for control, n = 58 for class I, n = 30 for class II, n = 24 for class III, n = 13 for class IV-V) (p < 0.0001). b ACh level distribution relative to QMG scores (n = 125) (p < 0.0001). c ACh content decreased in patient’s blood drawn before treatment and 2 weeks after initial treatment, respectively (p < 0.0001). d QMG scores also decreased in patients (p < 0.0001). (c-d; n = 30 in each group)