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. 2017 Feb 8;24:14. doi: 10.1186/s12929-017-0319-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic presentation of current pre-clinically tested drugs in neuroblastoma. A discussed anti-tumor drugs used against neuroblastoma in vitro and/or in vitro, and their targets are presented. In addition, a connection between the molecular targets is determined by the arrows. Legend shows a type of interaction described between the molecules a Indicates targeting of MYCN and P53/MDM dependent pathways. b Depicts drugs against ALK, Trk and PI3K/AKT/mTOR pathway. c Illustrates a targeting of main anti-apoptotic molecules. Gene symbol and its corresponding protein: NTRK1 – TrkA; NTRK2 – TrkB; PIK3CA - PI3K, BIRC5 – Survivin (Data resource: http://www.pathwaycommons.org/)