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. 2017 Feb 8;18:141. doi: 10.1186/s12864-017-3513-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Promoter analysis of canine adult β globins. Canine HBD1, HBD2 and HBB are aligned with their carnivore (panda, ferret and cat) and human and horse orthologs. Sequences known to be bound by regulatory proteins are shown in yellow if they match the consensus and red if they are non-consensus. Dog HBD1 appears to carry the ancestral HBD promoter sequence, whereas both dog HBD2 and cat HBD (italics/underline) show evidence of gene conversion with acquisition of the full HBB promoter sequence. As a result, those genes now have consensus CACC boxes, which are known to be bound by erythroid Krüppel-like Factor (EKLF) to activate HBB expression