Table 3.
Risk of diabetes according to sex-specific quartiles of hs-CRP: stratified by sex
| Quartiles of hs-CRPa | P for trendb | Per 1 log mg/L increase | ||||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| Men | ||||||
| Median (range) | 0.3 (0.12–0.4) | 0.8 (0.5–1.1) | 1.5 (1.2–2.0) | 3.4 (2.1–11.0) | ||
| Cases/controls | 22/60 | 70/64 | 59/53 | 85/59 | ||
| Model 1 | 1.00 | 2.79 (1.54–5.05) | 3.00 (1.60–5.63) | 3.73 (2.04–6.79) | 0.002 | 1.46 (1.21–1.75) |
| Model 2 | 1.00 | 3.42 (1.77–6.61) | 3.06 (1.53–6.13) | 3.57 (1.80–7.11) | 0.039 | 1.38 (1.12–1.70) |
| Model 3 | 1.00 | 2.76 (1.40–5.47) | 2.45 (1.20–5.03) | 2.80 (1.38–5.69) | 0.029 | 1.30 (1.05–1.61) |
| Model 4 | 1.00 | 2.86 (1.36–6.01) | 1.90 (0.86–4.19) | 2.25 (1.06–4.79) | 0.24 | 1.19 (0.94–1.49) |
| Women | ||||||
| Median (range) | 0.5 (0.12–0.7) | 1.1 (0.8–1.3) | 1.8 (1.4–2.5) | 4.3 (2.6–11.0) | ||
| Cases/controls | 44/94 | 56/79 | 87/82 | 148/80 | ||
| Model 1 | 1.00 | 1.53 (0.91–2.57) | 2.29 (1.38–3.80) | 3.86 (2.39–6.21) | <0.001 | 1.72 (1.44–2.04) |
| Model 2 | 1.00 | 1.37 (0.79–2.37) | 2.00 (1.16–3.46) | 3.32 (1.99–5.53) | <0.001 | 1.63 (1.36–1.96) |
| Model 3 | 1.00 | 1.10 (0.61–2.00) | 1.45 (0.80–2.66) | 2.19 (1.24–3.85) | 0.002 | 1.42 (1.16–1.73) |
| Model 4 | 1.00 | 1.09 (0.54–2.20) | 1.25 (0.63–2.47) | 2.07 (1.07–3.99) | 0.012 | 1.41 (1.12–1.78) |
Abbreviation: hs-CRP high-sensitive C-reactive protein, OR odds ratio, CI confidence interval
aQuartiles of hs-CRP were created separately for men and women among controls
bLinear trend was tested by using the median level of each quartile of hs-CRP as continuous variables
Model 1: adjusted for age (continuous variable), matched on age (±3 years), sex, dialect, and date of blood collection (±6 months)
Model 2: model 1 plus education level, smoking status, alcohol intake, physical activity, hypertension, and fasting status
Model 3: model 2 plus adjusted for body mass index (continuous)
Model 4: model 3 plus plasma triglycerides and HDL-cholesterol levels (both in quartiles)