Table 4.
Risk of diabetes according to quartiles of hs-CRP: stratified by baseline BMI
| Quartiles of hs-CRPa | P for trendb | Per 1 log mg/L increase | ||||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| Median (range) | 0.4 (0.1–0.6) | 0.9 (0.7–1.2) | 1.6 (1.3–2.3) | 3.6 (2.4–11.0) | ||
| BMI <23 kg/m2 | ||||||
| Cases/controls | 37/109 | 42/84 | 48/68 | 59/57 | ||
| Model 1 | 1.00 | 1.49 (0.88–2.53) | 2.08 (1.23–3.51) | 2.95 (1.75–4.99) | <0.001 | 1.47 (1.22–1.77) |
| Model 2 | 1.00 | 1.41 (0.82–2.43) | 1.93 (1.12–3.32) | 2.67 (1.54–4.60) | <0.001 | 1.42 (1.17–1.72) |
| Model 3 | 1.00 | 1.27 (0.71–2.25) | 1.38 (0.77–2.47) | 2.07 (1.16–3.70) | 0.02 | 1.29 (1.05–1.58) |
| BMI ≥23 kg/m2 | ||||||
| Cases/controls | 41/45 | 65/55 | 102/70 | 177/83 | ||
| Model 1 | 1.00 | 1.39 (0.79–2.44) | 1.74 (1.02–2.96) | 2.62 (1.56–4.41) | <0.001 | 1.55 (1.29–1.86) |
| Model 2 | 1.00 | 1.30 (0.73–2.33) | 1.43 (0.82–2.50) | 2.19 (1.28–3.78) | 0.002 | 1.46 (1.21–1.77) |
| Model 3 | 1.00 | 1.11 (0.60–2.05) | 1.20 (0.67–2.15) | 1.68 (0.95–2.97) | 0.041 | 1.33 (1.09–1.63) |
Abbreviation: hs-CRP high-sensitive C-reactive protein, BMI body mass index, OR odds ratio, CI confidence interval
aQuartiles of hs-CRP were created based on controls in the whole population
bLinear trend was tested by using the median level of each quartile of hs-CRP as continuous variables
Model 1: adjusted for age (continuous variable), sex, and dialect
Model 2: model 1 plus education level, smoking status, alcohol intake, physical activity, hypertension, and fasting status
Model 3: model 2 plus plasma triglycerides and HDL-cholesterol levels (both in quartiles)