Table 1.
Results of fitting the model to ARDS patient data of PaO2 and PaCO2
| Moderate ARDS, High CO [25] | Moderate ARDS, Normal CO [26] | Severe ARDS, High CO [27] | |||||
|---|---|---|---|---|---|---|---|
| Parameters obtained from data | CO (l min−1) | 8 | 4.09 | 7.3 | |||
| FIO2 | 0.5 | 0.45 | 1 | ||||
| Vt (ml kg−1) | 12 | 10 | 10 | ||||
| PEEP (cm H2O) | 0 | 0 | 0 | ||||
| Parameters determined by optimizationa | VR (b min−1) | 12 | 10 | 10 | |||
| Duty Cycle | 0.33 | 0.35 | 0.46 | ||||
| RQ | 0.9 | 0.9 | 0.7 | ||||
| VO2 (ml min−1) | 307 | 303 | 306 | ||||
| Hb (g dl−1) | 9.9 | 14.5 | 10.5 | ||||
| Data | Model | Data | Model | Data | Model | ||
| Results of fitting the model to the data | PaO2 (kpa) | 10.6 | 11.2 | 10 | 10.8 | 6.6 | 7.5 |
| PaCO2 (kpa) | 5 | 4.4 | 5.3 | 5.2 | 3.7 | 4.3 | |
| Other results | PvO2 (kpa) | NA | 4.6 | NA | 4.4 | NA | 4.1 |
| Shunt Fraction (%) | NA | 22 | NA | 16 | NA | 44 | |
List of Abbreviations CO cardiac output, FiO 2 fraction of O2 in inspired gas, Vt tidal volume, VR ventilator rate, PEEP positive end expiratory pressure, IE inspiratory to expiratory ratio, RQ respiratory quotient, VO 2 oxygen consumption, TOP threshold opening pressure, S alveolar stiffness factor, Pext extrinsic pressure, Hb hemoglobin in blood, PaO 2 arterial oxygen tension, PaCO 2 arterial carbon dioxide tension, PvO 2 mixed venous oxygen tension, shunt fraction
aOptimization methodology and parameter ranges given in Additional file 1