Table 2. Univariate and multivariate analyses to identify factors influencing early tumor recurrence in patients with HBV-related hepatocellular carcinoma after liver resection.

	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
Gender (female)	0.906 (0.389–2.110)	0.819	—	—
Age ≥60	0.916 (0.475–1.765)	0.793	—	—
AFP ≥200 ng/ml	0.984 (0.587–1.651)	0.952	—	—
HBV-DNA ≥1000 copies/ml	1.052 (0.568–1.948)	0.872	—	—
Cirrhosis	1.406 (0.667–2.965)	0.371	—	—
Tumor size >5 cm	2.396 (1.271–4.515)	0.007	2.513 (1.304–4.845)	0.006
Tumor number ≥2	1.468 (0.850–2.534)	0.068	1.921 (1.085–3.403)	0.025
Macrovascular invasion	2.680 (1.473–4.877)	0.001	2.824 (1.520–5.249)	0.001
Differentiation degree (poorly)	1.757 (1.057–2.924)	0.030	1.767 (1.054–2.967)	0.031
AKR1B10 expression (high)	0.555 (0.333–0.925)	0.024	0.572 (0.340–0.963)	0.036

Factors with a probability threshold of less than 0.100 in univariate analysis were selected into the multivariate Cox regression model. AFP, alpha-fetoprotein; CI, confidence interval; HBV, hepatitis B virus.