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. Author manuscript; available in PMC: 2017 Jun 2.
Published in final edited form as: Neuroscience. 2016 Mar 8;324:177–190. doi: 10.1016/j.neuroscience.2016.03.010

Figure 2.

Figure 2

mGluR II enhancement of KV currents is most prominent in LF neurons. A, DCG-IV (2 μM) increased KV currents in LF neurons (n = 9). B, The predominant change in KV currents was observed at voltage commands more positive than −20 mV, indicating a high threshold KV (HTK) current was affected by DCG-IV. C, DCG-IV produced a slight increase in KV currents in MF and HF neurons (n = 7). D, The change in KV currents in MF and HF NL neurons was significantly increased at Vcommand of −5 and +5 mV but not at −30 mV. E, The DCG-IV-sensitive current (DCG-IV KV currents minus control KV currents) has noticeable activation at about −20 mV, further confirming it is the HTK component. F, Activation τ at Vcommand of −5 mV reveals the DCG-IV-sensitive current is relatively slow (16.3 ± 6.3 ms, n = 7), indicating it is a delayed rectifying current. G, Percent change in KV was significantly larger for LF (open bars) compared to MF/HF (filled bars) neurons at Vcommand of −5 and +5 mV but not at −30 mV.