Figure 8.

Age-dependent modifications of epileptiform activity in TgproNGF#3 mice. (A–C left panels) Photographs of EC-HP slices obtained from a 1-, 3-, and 12-months old TgproNGF#3 mouse, respectively, placed over an array of 64 planar multi-electrodes, detectable in transparency through the slice. Colored dots indicate position of the electrodes, whose voltage signals appear in the corresponding colored area. (A–C right panels) Simultaneous recordings from each one of the 64 electrodes. (A–C insets) Trace records from the HP (red) and EC (green) detected by the colored electrodes in the corresponding photograph, showing no spontaneous activity in the EC of 1- and 3-months old mice, as opposed to spontaneous cortical events at 12-month, while the hippocampal area displays spontaneous events at all 3 ages.