Table 1.
Summary of the Studies on Malabsorptive Endoscopic Procedures in Obesity Treatment
| Duodenal-Jejunal Bypass Sleeve | ||||||
|---|---|---|---|---|---|---|
| Study | Subject | Duration | Technical success and Maintenance | Weight change (%EWL) | Change of glycemic control | Complications |
| Rodriguez-Grunert et al. (2008) [4] | 12 (including 4 diabetes) | 12 weeks | Maintenance: 10 Explantation: 2 at 9th day | 23.60% | 4 diabetes normal fasting glucose decrease of HbA1c: ≥0.5% | Abdominal pain, Nausea, Vomiting, Partial pharyngeal tear |
| Tarnoff et al. (2009) [5] | 25 (vs. 14 diet control) | 12 weeks | Maintenance: 20 Explantation: 5 (3 bleeding, 1 migration, 1 obstruction) | 22.1% (vs. 5.3% in diet alone) | 3 diabetes decrease of HbA1c: ≥0.5% | Abdominal pain (n=16), Nausea (n=7), Vomiting (n=8), Abdominal distension (n=11), GI hemorrhage (n=4), Constipation (n=1), and Epigastric discomfort (n=1) |
| Schouten et al. (2010) [6] | 30 vs. 11 diet control | 12 weeks | Technical success rate: 26 of 30 Maintenance: 22 of 26 | 19% (vs. 6.9% in diet alone) | 8 diabetes improved in 7 mean decrease of HbA1c: 2.3% | Migration, Dislocation of the anchor, Sleeve obstruction, Continuous epigastric pain, Nausea, Upper abdominal pain, Pseudopolyp formation (explant), Implant site inflammation (explant), Vomiting, Adverse drug reaction |
| Gersin et al. (2010) [7] | 25 vs. 26 sham control | 12 weeks | Technical success: 21 of 25 Maintenance: 13 of 21 | 11.9% (vs. 2.0% in sham group) | GI bleeding, Abdominal pain, Nausea, Vomiting | |
| de Moura et al. (2012) [8] | 22 diabetes | 52 weeks | Maintenance: 13 | 35.5% | Reduction of fasting blood glucose: –30.3±10.2 mg/dL reduction of HbA1c: –2.1±0.3% 16 of 22: HbA1c <7% | Migration, GI bleeding, Abdominal pain, Back pain, Nausea, Vomiting |
| Koehestanie et al. (2014) [9] | 38 diabetes vs. 39 diet control | 12 months | Technical success: 34 of 38 Complete study: 31 of 34 | 19.8% vs. 11.7% (diet control) | HbAlc: 7.3% (vs. 8.0%) | Abdominal pain |
| Nausea | ||||||
| Vomiting | ||||||
| Melena | ||||||
| Food impaction | ||||||
|
Gastroduodenal-Jejunal Bypass Sleeve | ||||||
| Study | Subject | Duration | Technical success rate | Weight change (%EWL) | Change of glycemic control | Complications |
| Sandler et al. (2011) [10] | 24 (7 diabetes) | 12 weeks | Technical success: 22 of 24 Complete study: 17 of 22 | 39.7% | 7 diabetes normalization of fasting blood glucose without medications improved HbAlc | Inflammation at the gastroesophageal junction Postoperative dysphagia |
| Sandler et al. (2015) [11] | 12 | 12 months | Technical success: 12 of 12 Complete study: 10 of 12 | 54% | 4 diabetes asting blood glucose improvement: 28% | Partial cuff detachment |
EWL, excess weight loss; HbA1c, glycated hemoglobin; GI, gastrointestinal.