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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Cancer Discov. 2016 Oct 12;7(1):38–53. doi: 10.1158/2159-8290.CD-16-0975

Figure 1. Crebbp deficiency accelerates B-cell lymphoma development in mice.

Figure 1

A, Kaplan-Meier curve of C57BL/6 mice transplanted with VavP-Bcl2 HPCs transduced with MSCV-GFP retroviral vector alone (GFP, black, n=31), or containing shRNAs against Crebbp (red, n=34). Statistical significance of survival difference was determined by the log-rank test between shCrebbp and vector alone. B, Representative flow cytometry histograms showing the GFP positive cell percentage of the pre-injection HPCs and the splenic murine lymphoma cells that derived from the same HPC. C, Dot plot representing the GFP positive cell percentage in the splenic murine lymphoma cells in individual recipient animal. The mean and standard error of the mean (S.E.M.) were represented for each transplant group. Statistical significance was determined by Mann-Whitney test. D, H&E, B220, CD3, and Ki67 staining of spleen tissues extracted from recipient mice upon sacrifice. Scale bars, 500 µm. E, H&E and B220 staining of kidney and lung tissues extracted from recipient mice upon sacrifice. Scale bars, 500 µm.