TABLE 3.
Univariate and Multivariate Analysis of Clinicopathologic Variables in Relation to Overall Survival in Patients With CRC Undergoing Curative Resection
| Clinicopathologic Characteristics | Univariate Analysis, HR (95% CI) | P | Multivariate Analysis, HR (95% CI) | P |
| Age | ||||
| ≤70 | 1 (Referent) | <0.001 | 1 (Referent) | <0.001 |
| >70 | 2.057 (1.713–2.470) | — | 1.981 (1.642–2.388) | — |
| Sex | ||||
| Female | 1 (Referent) | 0.162 | — | — |
| Male | 1.125 (0.953–1.328) | — | — | — |
| T Stage | ||||
| 1 | 1 (Referent) | <0.001 | 1 (Referent) | <0.001 |
| 2 | 0.985 (0.592–1.640) | — | 0.900 (0.540–1.498) | — |
| 3 | 1.805 (1.147–2.840) | — | 1.380 (0.873–2.182) | — |
| 4 | 4.834 (3.044–7.677) | — | 3.282 (2.039–5.282) | — |
| N stage | ||||
| 0 | 1 (Referent) | <0.001 | 1 (Referent) | <0.001 |
| 1 | 1.518 (1.254–1.837) | — | 1.246 (1.023–1.517) | — |
| 2 | 3.041 (2.444–3.785) | — | 2.299 (1.809–2.922) | — |
| Grade | ||||
| Low | 1 (Referent) | <0.001 | 1 (Referent) | 0.049 |
| Mod | 1.309 (1.066–1.606) | — | 1.293 (1.053–1.589) | — |
| High | 1.654 (1.303–2.100) | — | 1.148 (0.898–1.467) | — |
| Site | ||||
| Left-sided colon | 1 (Referent) | 0.618 | — | — |
| Right-sided colon | 1.062 (0.873–1.293) | — | — | — |
| Rectum | 0.949 (0.772–1.166) | — | — | — |
| MMR-BRAF status | ||||
| MMRp/BRAFV600E | 1 (Referent) | 0.002 | — | 0.146 |
| MMRd/BRAFwt | 0.644 (0.406–1.024) | — | — | — |
| MMRd/BRAFV600E | 0.533 (0.378–0.753) | — | — | — |
| MMRp/BRAFwt | 0.650 (0.506–0.836) | — | — | — |
| NLR | ||||
| Low (≤3.19) | 1 (Referent) | <0.001 | — | 0.124 |
| High (>3.19) | 1.830 (1.539–2.176) | — | — | — |
| LMR | ||||
| Low (≤2.38) | 1 (Referent) | <0.001 | 1 (Referent) | <0.001 |
| High (>2.38) | 0.486 (0.409–0.576) | — | 0.569 (0.478–0.677) | — |
| PLR | ||||
| Low (≤258) | 1 (Referent) | <0.001 | — | 0.592 |
| High (>258) | 1.592 (1.343–1.886) | — | — | — |
CI indicates confidence interval; HR, hazard ratio.