Table 1.
Individual Exclusion Criteria by Sex
| Exclusion Criteria | Overall (n=1837) | Women (n=1041, 58%) | Men (n=797, 42%) | P Value |
|---|---|---|---|---|
| Standard criteria | ||||
| Arrival >3 h | 1442 (78.0%) | 822 (79.1%) | 620 (76.5%) | 0.35 |
| Minor symptoms (NIHSS <5) | 1083 (60.1%) | 596 (60.0%) | 487 (60.2%) | 0.93 |
| SBP >185 mm Hg or DBP >110 mm Hg* | 277 (15.1%) | 176 (17.1%) | 101 (12.4%) | 0.02 |
| Stroke/head trauma in previous 3 mo* | 75 (5.4%) | 47 (5.6%) | 28 (5.3%) | 0.92 |
| INR >1.7* | 99 (7.5%) | 56 (9.1%) | 43 (5.3%) | 0.13 |
| aPTT value >40 s* | 100 (6.0%) | 60 (6.7%) | 40 (4.9%) | 0.29 |
| Seizure at presentation | 36 (1.9%) | 18 (1.6%) | 18 (2.2%) | 0.35 |
| Major surgery in preceding 14 days | 35 (1.8%) | 13 (1.2%) | 22 (2.7%) | 0.02 |
| Previous ICH* | 23 (1.2%) | 14 (1.2%) | 9 (1.1%) | 0.78 |
| Aneurysm* | 20 (1.0%) | 11 (1.0%) | 9 (1.1%) | 0.80 |
| Platelets <100 000* | 28 (1.4%) | 13 (1.2%) | 15 (1.8%) | 0.23 |
| MI in previous 3 mo | 10 (0.5%) | 3 (0.3%) | 7 (0.9%) | 0.10 |
| GI/urinary tract hemorrhage in previous 21 days | 1 (0.05%) | 1 (0.1%) | 0 (0%) | … |
| Serum glucose <50 mg/dL* | 1 (0.05%) | 0 (0%) | 1 (0.1%) | … |
| Brain tumor* | 6 (0.3%) | 4 (0.4%) | 2 (0.2%) | 0.65 |
| AVM* | 0 (0%) | 0 (0%) | 0 (0%) | … |
| Active bleeding/acute trauma* | 0 (0%) | 0 (0%) | 0 (0%) | … |
| Noncompressible arterial puncture previous 7 days* | 0 (0%) | 0 (0%) | 0 (0%) | … |
| ECASS III criteria | ||||
| Arrival >4.5 h* | 1377 (74.7%) | 785 (75.8%) | 592 (73.1%) | 0.33 |
| Age >80 y | 496 (27.6%) | 358 (35.0%) | 138 (17.4%) | <0.0001 |
| History of DM and prior stroke | 216 (11.9%) | 118 (11.9%) | 98 (12.0%) | 0.95 |
| Any oral anticoagulant use or heparin use with aPTT >40* | 237 (13.8%) | 134 (14.7%) | 103 (12.6%) | 0.39 |
| NIHSS >25 | 42 (2.2%) | 32 (2.8%) | 10 (1.2%) | 0.01 |
Data are reported as raw counts and weighted percentages. Generalized linear models were used for analysis to account for the study design. AVM indicates arteriovenous malformation; DBP, diastolic blood pressure; DM, diabetes mellitus; GI, gastrointestinal; ICH, intracerebral hemorrhage; MI, myocardial infarction; NIHSS, National Institutes of Health Stroke Scale; PTT, partial thromboplastin time; and SBP, systolic blood pressure.
*
Absolute exclusion criteria.