Table 1. Genotype distributions and allelic frequencies of the polymorphisms in the SLC6A3 (DAT) gene between patients with alcohol dependence and controls in a Han Chinese population.
| Variant | Position reference dSNP | Allele a | MAF a (%) | p b | Genotype (%) | p b | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | Control | AD | Control (N = 523) | AD (N = 637) | p b | LOAD (N = 408) | ||||||||||
| 1/1 | 1/2 | 2/2 | 1/1 | 1/2 | 2/2 | 1/1 | 1/2 | 2/2 | |||||||||
| rs2550948 | 1503444(P) | A | G | 13.00 | 15.78 | 0.059 | 10 (1.9) | 116 (22.2) | 397 (75.9) | 12 (1.9) | 177 (27.8) | 448 (70.3) | 0.091 | 9 (2.2) | 114 (27.9) | 285 (69.9) | 0.115 |
| rs2652511 | 1499389(P) | C | T | 14.34 | 16.56 | 0.142 | 12 (2.3) | 126 (24.1) | 385 (73.6) | 12 (1.9) | 187 (29.4) | 438 (68.8) | 0.126 | 9 (2.2) | 121 (29.7) | 278 (68.1) | 0.161 |
| rs2975226 | 1498616(P) | A | T | 14.63 | 16.56 | 0.202 | 13 (2.5) | 127 (24.3) | 383 (73.2) | 12 (1.9) | 187 (29.4) | 438 (68.8) | 0.134 | 9 (2.2) | 121 (29.7) | 278 (68.1) | 0.183 |
| rs6350 | 1496199(E2) | A | G | 1.24 | 2.83 | 0.008 | 0 (0) | 13 (2.5) | 510 (97.5) | 0 (0.0) | 36 (5.7) | 602 (94.5) | 0.008c | 0 (0) | 27 (6.6) | 381 (93.4) | 0.003c |
| rs2981359 | 1495732(In2) | G | C | 43.31 | 44.03 | 0.726 | 95 (18.2) | 263 (50.3) | 165 (31.5) | 124 (19.5) | 313 (49.1) | 200 (31.4) | 0.845 | 81 (19.9) | 202 (49.5) | 125 (30.6) | 0.805 |
| rs403636 | 1491354(In3) | A | C | 32.98 | 33.20 | 0.911 | 53 (10.1) | 239 (45.7) | 231 (44.2) | 73 (11.5) | 277 (43.5) | 287 (45.1) | 0.660 | 41 (10.0) | 183 (44.9) | 184 (45.1) | 0.960 |
| rs460000 | 1485825(In3) | G | T | 46.08 | 48.51 | 0.244 | 104 (19.9) | 274 (52.4) | 145 (27.7) | 147 (23.1) | 324 (50.9) | 166 (26.1) | 0.411 | 87 (21.3) | 221 (54.2) | 100 (24.5) | 0.531 |
| rs460700 | 1482969(In4) | T | C | 47.04 | 49.84 | 0.178 | 111 (21.2) | 270 (51.6) | 142 (27.2) | 157 (24.6) | 321 (50.4) | 159 (25.0) | 0.355 | 97 (23.8) | 216 (52.9) | 95 (23.3) | 0.352 |
| rs464049 | 1476905(In4) | A | G | 36.42 | 36.50 | 0.970 | 69 (13.2) | 243 (46.5) | 211 (40.3) | 94 (14.8) | 277 (43.5) | 266 (41.8) | 0.547 | 54 (13.2) | 184 (45.1) | 170 (41.7) | 0.909 |
| rs37020 | 1471374(In6) | A | C | 35.37 | 36.34 | 0.628 | 61 (11.7) | 248 (47.4) | 214 (40.9) | 93 (14.6) | 277 (43.5) | 267 (41.9) | 0.233 | 59 (14.5) | 178 (43.6) | 171 (41.9) | 0.339 |
| rs37022 | 1468629(In7) | T | A | 50.38 | 47.33 | 0.144 | 137 (26.2) | 253 (48.4) | 133 (25.4) | 153 (24.0) | 297 (46.6) | 187 (29.4) | 0.311 | 101 (24.8) | 182 (44.6) | 125 (30.6) | 0.210 |
| rs27048 | 1465645(In8) | T | C | 15.68 | 15.86 | 0.908 | 12 (2.3) | 140 (26.8) | 371 (70.9) | 9 (1.4) | 184 (28.9) | 444 (69.7) | 0.416 | 6 (1.5) | 116 (28.4) | 286 (70.1) | 0.589 |
| rs6347 | 1464412(E9) | G | A | 12.43 | 11.15 | 0.339 | 4 (0.8) | 122 (23.3) | 397 (75.9) | 10 (1.6) | 122 (19.2) | 505 (79.3) | 0.111c | 5 (1.2) | 84 (20.6) | 319 (78.2) | 0.518c |
| rs11133767 | 1454580(In13) | T | C | 11.19 | 10.13 | 0.409 | 14 (2.7) | 89 (17.0) | 420 (80.3) | 11 (1.7) | 107 (16.8) | 519 (81.5) | 0.533 | 7 (1.7) | 72 (17.6) | 329 (80.6) | 0.608 |
| rs40184 | 1448077(In14) | T | C | 25.53 | 25.12 | 0.822 | 30 (5.7) | 207 (39.6) | 286 (54.7) | 37 (5.8) | 246 (38.6) | 354 (55.6) | 0.946 | 23 (5.6) | 147 (36.0) | 238 (58.3) | 0.521 |
| rs27072 | 1447522(E15) | T | C | 27.44 | 24.65 | 0.127 | 45 (8.6) | 197 (37.7) | 281 (53.7) | 37 (5.8) | 240 (37.7) | 360 (56.5) | 0.167 | 26 (6.4) | 152 (37.3) | 230 (56.4) | 0.407 |
MAF, minor allele frequency; P, promoter; E, exon; In, intron; AD: Alcohol dependence; LOAD: late-onset alcohol dependence.
a Allele 1 is the minor allele, and only alleles with frequency higher than 1% are shown.
b Indicated genotype or allelic frequencies in patients with AD or LOAD compared with the control group.
c Statistical analysis was performed by Fisher’s exact test.