Table 4. Linear regression analysis between SLC6A3 (DAT) gene polymorphisms and personality traits in patients with AD (215 patients completed TPQ).
| Variants | Novelty Seeking a | Harm Avoidance a | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Age | Gender | Age of onset | Genotype | Age | Gender | Age of onset | |||
| β (SE) | β (SE) | β (SE) | β (SE) | p value b | β (SE) | β (SE) | β (SE) | β (SE) | p value b | |
| rs2550948 | −0.625 (0.613) | −0.184 (0.033) | 0.287 (1.015) | −0.132 (0.766) | 0.309 | 2.059 (0.825) | −0.116 (0.044) | −2.012 (1.366) | 1.396 (1.032) | 0.013 |
| rs2652511 | −0.679 (0.612) | −0.185 (0.033) | 0.301 (1.015) | −0.147 (0.767) | 0.268 | 2.004 (0.825) | −0.116 (0.044) | −2.011 (1.368) | 1.417 (1.034) | 0.016 |
| rs2975226 | −0.679 (0.612) | −0.185 (0.033) | 0.301 (1.015) | −0.147 (0.767) | 0.268 | 2.004 (0.825) | −0.116 (0.044) | −2.011 (1.368) | 1.417 (1.034) | 0.016 |
| rs6350 | −0.007 (1.473) | −0.184 (0.033) | 0.167 (1.019) | −0.070 (0.766) | 0.996 | 1.133 (2.008) | −0.118 (0.045) | −1.517 (1.389) | 1.182 (1.044) | 0.573 |
| rs2981359 | 0.031 (0.431) | −0.184 (0.033) | 0.163 (1.013) | −0.067 (0.767) | 0.931 | −0.297 (0.588) | −0.117 (0.045) | −1.575 (1.381) | 1.160 (1.046) | 0.613 |
| rs403636 | 1.048 (0.534) | −0.186 (0.033) | 0.387 (1.007) | −0.001 (0.759) | 0.051 | −1.534 (0.727) | −0.115 (0.044) | −1.939 (1.372) | 1.090 (1.034) | 0.036 |
| rs460000 | 0.584 (0.467) | −0.185 (0.033) | 0.133 (1.007) | −0.002 (0.765) | 0.212 | −0.195 (0.639) | −0.118 (0.045) | −1.606 (1.379) | 1.167 (1.047) | 0.760 |
| rs460700 | −0.646 (0.463) | −0.185 (0.033) | 0.103 (1.007) | −0.019 (0.763) | 0.165 | 0.113 (0.635) | −0.118 (0.045) | −1.607 (1.380) | 1.181 (1.046) | 0.858 |
| rs464049 | 1.115 (0.491) | −0.186 (0.032) | 0.324 (1.000) | −0.003 (0.757) | 0.024 | −1.349 (0.671) | −0.115 (0.044) | −1.807 (1.368) | 1.109 (1.035) | 0.046 |
| rs37020 | −1.302 (0.485) | −0.183 (0.032) | 0.366 (0.995) | −0.123 (0.752) | 0.008 | 1.232 (0.668) | −0.119 (0.044) | −1.806 (1.371) | 1.240 (1.036) | 0.067 |
| rs37022 | 0.474 (0.430) | −0.184 (0.033) | 0.130 (1.008) | −0.053 (0.764) | 0.272 | −0.176 (0.588) | −0.118 (0.045) | −1.604 (1.379) | 1.184 (1.045) | 0.765 |
| rs27048 | 0.757 (0.620) | −0.179 (0.033) | 0.187 (1.007) | −0.124 (0.764) | 0.223 | −0.982 (0.846) | −0.125 (0.045) | −1.643 (1.374) | 1.261 (1.043) | 0.247 |
| rs6347 | 0.126 (0.763) | −0.184 (0.033) | 0.175 (1.012) | −0.068 (0.766) | 0.869 | −0.601 (1.040) | −0.118 (0.045) | −1.652 (1.379) | 1.181 (1.044) | 0.564 |
| rs11133767 | −0.199 (0.744) | −0.184 (0.033) | 0.182 (1.012) | −0.064 (0.766) | 0.790 | 1.159 (1.011) | −0.118 (0.045) | −1.703 (1.376) | 1.155 (1.011) | 0.253 |
| rs40184 | 0.076 (0.552) | −0.183 (0.034) | 0.170 (1.011) | −0.093 (0.785) | 0.891 | −0.932 (0.750) | −0.131 (0.046) | −1.655 (1.374) | 1.481 (1.067) | 0.215 |
| rs27072 | 0.057 (0.523) | −0.184 (0.033) | 0.167 (1.011) | −0.064 (0.768) | 0.914 | 1.336 (0.706) | −0.127 (0.045) | −1.628 (1.366) | 1.321 (1.037) | 0.055 |
AD, alcohol dependence; TPQ, Tridimensional Personality Questionnaire.
a The association between all SLC6A3 variants and TPQ score are corrected for age, gender, and age of onset as covariates using linear regression analysis.
b The p value for the relationship between TPQ score and each SLC6A3 variant.