Table 2. Fold change ratios in the gene expression of septic patients compared to the healthy volunteers at admission and after seven days of follow-up, according to the outcomes.
| D0 | D7 | |||
|---|---|---|---|---|
| Gene | All (N = 16) | S (N = 8) | NS(N = 8) | All (N = 10) |
| TLR4 | 1.08 | -1.06 | 1.25 | 1.05 |
| CD14 | 1.17 | 1.05 | 1.34 | -1.11 |
| LY96 | 1.1 | 1.02 | 1.24 | -1.12 |
| MYD88 | 1.1 | -1.06 | 1.25 | -1.01 |
| IRAK3 | 1.41 | 1.21 | 1.64 a | 1.3 |
| TRAF6 | -1.81 a | -1.70 a | -2.14 a | -1.47 |
| ECSIT | -1.3 | -1.31 | -1.35 | -1.23 |
| IRF5 | -1.22 | -1.08 | -1.35 | -1.11 |
| CHUK | -1.04 | -1.21 | 1.01 | -1.1 |
| IKBKG | -1.12 | -1.09 | -1.14 | 1.09 |
| NFKBIA | 1.22 | -1.21 | 1.62 | 1.35 |
| NFKB1 | 1.09 | 1.17 | 1.08 | -1.16 |
| RELA (p65) | -1.41 | -1.38 | -1.45 | -1.34 |
| MAPK7 (ERK) | -1.86 a | -1.69 a | -2.14 a | -1.66 a |
| MAP2K3 (MKK3) | 1.29 | 1.2 | 1.52 a | 1.05 |
| MAPK14 | 1.24 | 1.21 | 1.32 | 1.25 |
| MAP2K7 (MKK7) | -1.49 | -1.39 | -1.66 a | -1.25 |
| MAPK8 (JNK1) | -1.74 a | -1.69 a | -1.85 a | -1.41 |
| JUN (AP1) | -2.05 a | -1.70 | -2.78 a | -1.43 |
| TICAM1 | -1.11 | -1.33 | 1 | -1.17 |
| IRF7 | -1.54 a | -1.73 a | -1.50 | -1.35 |
| IRF3 | -1.61 a | -1.58 | -1.70 a | -1.37 |
| IFNAR1 | -1.23 | -1.08 | -1.51 a | -1.27 |
| IFNAR2 | -1.2 | -1.12 | -1.39 | -1.53 |
| JAK1 | -1.80 a | -1.68 a | -2.22 a | -1.64 |
| TYK2 | -1.37 | -1.31 | -1.47 | -1.29 |
| STAT1 | -1.78 a | -2.46 a | -1.80 | -1.13 |
| STAT2 | -1.58 a | -1.72 | -1.77 a | -1.36 |
| IRF9 | -1.52 a | -1.66 a | -1.61 a | -1.19 |
| IFNGR1 (IFNGR) | 1.04 | 1.13 | 1.04 | 1.11 |
| IFNGR2 (AF-1) | 1.46 | 1.4 | 1.60 a | 1.23 |
| JAK2 | -1.48 | -1.69 | -1.57 | -1.17 |
| SOCS3 | -1.07 | -1.02 | -1.22 | -1.23 |
| IRF1 | -1.94 a | -2.37 a | -2.17 a | -1.36 |
| NOS1 | 1 | -1.35 | 1.46 | -1.4 |
| NOS2 | -1.09 | -1.02 | -1.12 | -1.34 |
| NOS3 | -2.54 | -1.91 | -3.52 a | -1.85 |
| SOD1 | -1.6 | -1.4 | -2.02 a | -1.56 a |
| SOD2 | 2.15 a | 1.37 | 3.45 a | 2.12 a |
| SOD3 | -1.35 | -1.59 | 1.03 | -1.12 |
| CYBB (gp91) | -1.1 | -1.35 | 1.11 | -1.1 |
| NCF1 (p47phox) | 1.15 | -1.06 | 1.52 | 1.56 |
| RAC1 | -1.03 | -1.05 | -1.12 | -1.04 |
| UCP2 | -1.31 | -1.42 | -1.38 | -1.1 |
| GPX1 | 1.34 | 1.41 | 1.46 | 1.58 a |
| PRDX3 | -1.07 | -1.02 | -1.27 | -1.17 |
| PRDX4 | -1.04 | 1.13 | -1.35 | 1 |
| CAT | 1 | -1.02 | -1.03 | -1.15 |
| TXN | 1.11 | 1.1 | 1.17 | 1.03 |
| TXNRD1 | -1.12 | -1.11 | -1.22 | -1.07 |
| TXNRD2 | -1.22 | -1.22 | -1.26 | -1.21 |
| NDUFA4 | -1.41 | -1.37 | -1.55 a | -1.31 |
| NDUFA5 | -1.41 | -1.06 | -1.86 a | -1.22 |
| NDUFA7 | -1.35 | -1.34 | -1.54 a | -1.26 |
| NDUFA8 | -1.18 | -1.17 | -1.28 | -1.11 |
| NDUFA9 | -1.38 | -1.37 | -1.49 | -1.21 |
| NDUFA10 | -1.39 | -1.28 | -1.57 a | -1.28 |
| NDUFA11 | -1.19 | -1.15 | -1.16 | -1.21 |
| NDUFB5 | -1.45 | -1.35 | -1.73 a | -1.33 |
| NDUFB6 | -1.37 | -1.31 | -1.58 a | -1.22 |
| NDUFC2 | -1.90 a | -1.77 | -2.31 a | -1.58 a |
| COX4I2 | -1.83 a | -1.91 | -1.62 | -1.39 |
| COX5A | -1.15 | -1.02 | -1.36 | -1.16 |
| COX5B | -1.29 | -1.33 | -1.28 | -1.19 |
| COX6A2 | 1.18 | -1.01 | 1.31 | -1.26 |
| COX7A2 | -1.29 | -1.12 | -1.59 a | -1.36 |
| COX7C | -1.49 | -1.4 | -1.67 a | -1.34 |
| COX10 | -1.66 a | -1.65 | -1.74 a | -1.30 |
| ATP5B | -1.2 | -1.16 | -1.27 | -1.17 |
| ATP5C1 | -1.32 | -1.22 | -1.56 a | -1.28 |
| ATP5F1 | -1.4 | -1.26 | -1.76 a | -1.34 |
| ATP5J | -1.18 | -1.12 | -1.33 | -1.18 |
| ATP6V1C1 | 1.22 | 1.24 | 1.12 | 1.04 |
| ATP6V1E1 | -1.17 | -1.13 | -1.23 | -1 |
| ATP6V1E2 | -1.56 | -1.28 | -1.97 a | -1.51 a |
| UQCRC2 | -1.41 | -1.46 | -1.43 | -1.29 |
| TNF | 1.04 | -1.99 | 1.54 | 1.3 |
| IL1B | 1.38 | -2.24 | 2.9 | 1.56 |
| IFNA1 | -1.04 | -1.05 | 1.18 | -1.16 |
| IFNB1 | 1.12 | -1.49 | 1.67 | 1.58 |
| IL10 | 1.96 | 2.87 a | 1.73 | 1.22 |
| IL6 | 3.6 | 1.08 | 7.42 | 2.23 |
| CXCL10 | -2.49 | -5.16 | -2.02 | -1.49 |
| IL12A | -1.5 | -1.28 | -2.29 a | -1.22 |
Footnote: D0 represents total septic patients after admission and D7 represents samples obtained after 7 days. S: survivors and NS: non-survivors. The bold letters show fold change ≥1.5 and the letter “a” indicates P value ≤0.05.