Skip to main content
. 2017 Feb 9;12(2):e0171127. doi: 10.1371/journal.pone.0171127

Fig 3. Effect of (CUG)7 treatment on motor performance of R6/2 mice.

Fig 3

The effect of repeated ICV administration of (CUG)7 AON on body weight (A), total rearing frequency (B) and rotarod performance (C) of pooled genders (n = 22–31), female (n = 11–17)and male (n = 11–15) R6/2 mice from 4–12 weeks of age. (A) Body weight data over time are presented as mean ± SEM. Significance was assessed using One Way ANOVA on R6/2 groups followed by Dunnett’s multiple comparison posthoc test (*p < 0.05 compared to R6/2 VEH). A significant increase in body weight was observed in males at weeks 11 and 12 in the high dose group and at week 11 in the low dose group. (B) Vertical activity in the open field, also known as rearing, is represented as mean ± SEM. Significance was assessed using One Way ANOVA on R6/2 groups only followed by Dunnett’s multiple comparison posthoc test (*p<0.05 compared to R6/2 VEH). A significant increase in vertical count was observed in pooled genders at weeks 6, 8 and 12 in the high dose group and at week 8 in the low dose group, in females at weeks 6, 8 and 12 in the high dose group and in males at week 8 in the low dose group. (C) In the rotarod three consecutive accelerating trials were performed each week, indicated by 1, 2 and 3 and the latency to fall from the rod was recorded. Data are presented as mean ± SEM. Significance was assessed using One Way ANOVA on R6/2 groups followed by Dunnett’s multiple comparison posthoc test (*p < 0.05, **p<0.01 compared to R6/2 VEH).