Table 1. Overview of (CUG)7 treatment effects observed on fine motor performance.
| ANOVA p-value | Posthoc p-value | ||
|---|---|---|---|
| (CUG)7 L | (CUG)7 H | ||
| Fine Motor and Gait (Age Week 10): | |||
| - Stride Speed | p = 0.049 (f+m) | NS (f+m) | ▲p = 0.028 (f+m) |
| - Stride Distance | p = 0.007 (f+m) | NS (f+m) | ▲p = 0.004 (f+m) |
| - Swing Peak Speed Fore | p = 0.015 (f+m) | ▲p = 0.032 (f+m) | ▲p = 0.016 (f+m) |
| p = 0.013 (f) | ▲p = 0.032 (f) | ▲p = 0.012 (f) | |
| - Swing Jerk Metric Hind | p = 0.032 (m) | NS (m) | ▲p = 0.026 (m) |
| - Nose Height | p = 0.006 (f+m) | NS (f+m) | ▲p = 0.004 (f+m) |
| p = 0.003 (f) | NS (f) | ▲p = 0.003 (f) | |
| p = 0.015 (m) | NS (m) | ▲p = 0.026 (m) | |
| - Paw Lift-off Angle Hind | p = 0.001 (f+m) | ▲p = 0.001 (f+m) | NS (f+m) |
| p = 0.011 (f) | ▲p = 0.027 (f) | ▲p = 0.010 (f) | |
| p = 0.003 (f) | ▲p = 0.006 (m) | NS (m) | |
| - Swing Traj Over Tresh 25 Hind | p = 0.020 (f+m) | ▲p = 0.038 (f+m) | NS (f+m) |
| - Swing Traj Over Tresh 40 Hind | p = 0.019 (f+m) | ▲p = 0.024 (f+m) | NS (f+m) |
| - Swing Traj Over Tresh 50 Hind | p = 0.038 (f+m) | ▲p = 0.030 (f+m) | NS (f+m) |
| p = 0.019 (f) | ▲p = 0.017 (f) | NS (f) | |
| - Swing Traj Over Tresh 60 Hind | p = 0.019 (f) | ▲p = 0.018 (f) | NS (f) |
| - Horizontal Distance of Front Paw Trajectory | |||
| p = 0.008 (f+m) | NS (f+m) | ▲p = 0.007 (f+m) | |
| - PC3 | p = 0.042 (f) | NS (f) | ▲p = 0.028 (f) |
| - PC7 | p = 0.018 (f) | NS (f) | ▲p = 0.012 (f) |
| - Dist. from WT | p = 0.028 (f+m) | NS (f+m) | ▲p = 0.016 (f+m) |
| p = 0.020 (f+m) | NS (f+m) | ▲p = 0.011 (f+m) | |
| p = 0.026 (f) | NS (f) | ▲p = 0.015 (f) | |
P-values of each analysis are indicated, for the one way ANOVA (all R6/2 groups) and posthoc testing (comparison to VEH). The arrows indicate the change of the parameter towards WT levels. NS: not significant. m: males; f: females.