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. 2017 Feb;58(2):933–943. doi: 10.1167/iovs.16-19782

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Copyright 2017 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Effect of human macrophages CM on mRNA expression levels of claudin-2, claudin-5, and cadherin-4 (CDH4) in hRECs. Claudin-5 mRNA level in hRECs was significantly decreased after treatment with AGA-treated macrophage CM compared with the CM of control macrophages (*P < 0.05 versus control CM group). The AGA-treated macrophage CM did not show significant decreases in claudin-2 and cadherin-4 (CDH4) mRNA levels compared with the CM of control macrophages (P > 0.05). Conditioned medium of miR-146b-3p–transfected AGA-treated macrophages showed significant restoration of the levels of claudin-5 and CDH-4 compared with the cells treated with the CM of AGA-treated macrophages (^#P < 0.05).