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. 2017 Feb;58(2):933–943. doi: 10.1167/iovs.16-19782

Figure 8.

Figure 8

Effect of human macrophages CM on leukocyte/endothelial cell interaction. (A) Effect of the CM of AGA-, albumin-, or control-treated macrophages or direct AGA or albumin treatment on leukocyte adhesion to hRECs. Fold change of MPO activity (indicator of leukocyte adhesion) showing significant increases in leukocyte adhesion after treatment with the CM of AGA-treated macrophages compared with the CM of control macrophages or albumin-treated macrophages (*P < 0.05 versus control CM group, #P < 0.05 versus albumin CM group). Direct treatment of hRECs with AGA did not show any significant increases in leukocyte adhesion compared with albumin treatment (P > 0.05; n = 6). (B) Effect of the CM of miR-146b-3p–transfected AGA-treated macrophages on leukocyte adhesion to hRECs. Fold change of MPO activity (indicator of leukocyte adhesion) showing significant decreases in leukocyte adhesion after treatment with the CM of miR-146b-3p–transfected AGA-treated macrophages compared with the CM of control miR-transfected AGA-treated macrophages (*P < 0.05 versus control miR CM group; n = 6).