Skip to main content
. 2017 Feb 9;12(2):e0171819. doi: 10.1371/journal.pone.0171819

Fig 4. Effect of pretreatment with RKT on paclitaxel (single injection)-induced mechanical hyperalgesia in mice.

Fig 4

(A) Time course of the effect of RKT (0.1, 0.3, 1 g/kg p.o.) on the mean mechanical threshold in paclitaxel-treated mice. (B) Effect of RKT (0.1, 0.3, 1 g/kg p.o.) on the mean mechanical threshold in paclitaxel-treated mice on day 3. RKT was administered 24 hours before the injection of paclitaxel (5 mg/kg, i.p.). RKT was administered 1 hour before each nociceptive test. The nociceptive threshold was determined by the von Frey filament test. Each point represents the mean ± S.E.M of 8–9 mice. *P < 0.05, ***P < 0.001 vs. 10%DMSO-DW group. ###P < 0.001 vs. paclitaxel-DW group.