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. 2017 Jan 30;13(1):e1006131. doi: 10.1371/journal.ppat.1006131

Fig 1. Overview of two component-mediated regulation of the Hog1 SAPK in S. cerevisiae.

Fig 1

Under non-stress conditions the Sln1 histidine kinase autophosphorylates, and this phosphate is transferred via the Ypd1 phosphorelay protein to the Ssk1 response regulator protein. Following osmotic stress Sln1 is inactivated, thus halting the phosphorelay which culminates in unphosphorylated Ssk1 which is a potent activator of the Ssk2 MAPKKK. This results in the phosphorylation and activation of the downstream Hog1 SAPK.