Table 3.
Stepwise Univariate and Multivariate Cox Regression Analyses to Identify Predictors of Grade ≥ 3 RP
| Characteristics | Univariate Analysis (RP ≥ grade 3) |
Multivariate Analysis (RP ≥ grade 3)⁎ |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (≥66 vs <66) | 1.545 | 0.993-2.401 | .054 | 1.502 | 0.944-2.39 | .086 |
| Gender (male vs female) | 1.188 | 0.764-1.848 | .443 | 0.919 | 0.574-1.472 | .726 |
| Race (black and other vs white) | 1.048 | 0.568-1.934 | .881 | 0.74 | 0.388-1.411 | .36 |
| Disease stage (IIIB, IV, recurrence vs I-IIIA) | 0.779 | 0.499-1.217 | .273 | 0.696 | 0.437-1.107 | .126 |
| Histology (SCC & other vs Adn) | 0.968 | 0.625-1.498 | .883 | 0.969 | 0.606-1.549 | .894 |
| KPS (≥80 vs <80) | 0.51 | 0.305-0.852 | .01 | 0.416 | 0.24-0.722 | .002 |
| Concurrent chemotherapy (yes vs no) | 1.032 | 0.516-2.064 | .928 | 1.24 | 0.537-2.866 | .614 |
| Smoking status (current/former vs never) | 1.123 | 0.489-2.580 | .784 | 0.834 | 0.333-2.088 | .698 |
| Total dose (≥69.03 vs <69.03 Gy) | 0.657 | 0.421-1.026 | .065 | 0.758 | 0.468-1.227 | .26 |
| GTV (≥95.19 vs <95.19 cm3) | 2.76 | 1.678-4.539 | <.001 | 2.124 | 1.262-3.577 | .005 |
| MLD (≥17.93vs <17.93 Gy) | 3.922 | 2.318-6.639 | <.001 | 3.844 | 2.1-7.038 | <.001 |
| Technique (proton vs 3D-CRT + IMRT) | 0.65 | 0.359-1.176 | .154 | 1.395 | 0.823-2.363 | .216 |
| Muc5b rs35705950 (TT/GT vs GG) | 1.009 | 0.728-1.399 | .958 | 1.614 | 0.92-2.831 | .095 |
⁎
The propensity score was used for adjustments of confounders in the multivariate analysis.