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Type I versus II NKT cells
| Type I NKT | Type II NKT | |
|---|---|---|
| Restriction Element | CD1d | CD1d |
| T Cell Receptor | Vα14-Ja18 with Vβ8,7 or 2 (mice) Vα24-Jα18 with Vβ11 (human) |
Diverse but oligoclonal |
| Transcription Factor | PLZF (high) | PLZF (low) |
| Reactive to α-GalCer | Yes | No |
| Ligands | α-GalCer | Sulfatide, Lyso-sulfatide, Lyso-PC, Lyso-GL1 |
| Prevalence | More prevalent than type II NKT in mice |
More prevalent than type I NKT in human |
| Subsets | NKT-1, NKT-2, NKT-17 | Subsets to be determined |
