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. Author manuscript; available in PMC: 2017 Feb 9.
Published in final edited form as: J Clin Gastroenterol. 2011 Oct;45(9):800–807. doi: 10.1097/MCG.0b013e31821377e4

Table 3.

Comparison of demographic, laboratory, immunohistochemical, and histological data for non-NASH NAFLD patients and children with NASH

Non-NASH NAFLD (n=10) NASH (n=49) p-value
Male/Female 7/3 39/10
Age (yr) 12.7 ± 4.5 13.4 ± 2.7 0.684
BMI (kg/m2) 33.6 ± 8.9 35.2 ± 6.1 0.844
Glycemic Measures
 Glucose (mg/dl) 105.0 ± 32.6 96.8 ± 18.6 0.339
 Insulin (mcU/ml) 18.8 ± 9.0 27.2 ± 17.8 0.719
 HOMA 4.3 ± 2.4 6.9 ± 5.3 0.582
 HbA1c (%) 6.2 ± 2.2 5.3 ± 0.4 0.180
Lipids
 Total Cholesterol (mg/dl) 160.1 ± 19.6 171.5 ± 35.8 0.321
 LDL Cholesterol (mg/dl) 71.8 ± 34.3 69.4 ± 47.7 0.618
 HDL Cholesterol (mg/dl) 69.3 ± 38.9 70.5 ± 40.3 0.896
 Triglycerides (mg/dl) 99.9 ± 21.7 167.7 ± 105.4 0.053
Liver Biochemistries
 ALT (U/L) 77.4 ± 41.8 119.9 ± 88.1 0.045
 AST (U/L) 47.7 ± 28.1 71.0 ± 41.3 0.035
 Albumin (GM/dl) 3.9 ± 0.2 4.1 ± 0.4 0.031
Immunohistochemistry
 Malondialdehyde (MDA) content (%) 38.7 ± 19.7 48.3 ± 20.8 0.233
 CYP2E1 protein content (%) 58.5 ± 11.4 61.1 ± 8.1 0.746
 Steatosis (%) 9.5 ± 6.3 11.0 ± 6.1 0.780
Histological Scoring
 Steatosis grade 1.6 ± 1.0 1.9 ± 0.8 0.437
 Fibrosis stage 0 2.8 ± 1.8 <0.001
 Grade of lobular inflammation 0.8 ± 0.6 1.1 ± 0.6 0.169
 Grade of portal inflammation 0.4 ± 0.5 0.8 ± 0.6 0.056
 Hepatocyte ballooning 0 1.0 ± 0.8 <0.001

Values expressed are mean ± SD and immunohistochemical measures are as a percent of total liver biopsy area. Note that diagnoses were based on histological scoring criteria and statistical comparisons between groups should be interpreted accordingly.

Abbreviations: BMI, body mass index; HOMA, Homeostatic Model Assessment Method; HbA1c, glycosylated hemoglobin; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase.