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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Eur J Pain. 2016 Sep 15;21(3):456–465. doi: 10.1002/ejp.939

Figure 1.

Figure 1

EDPs, the omega-3 DHA derived epoxidized metabolites, mediate analgesia in a model of diabetic neuropathic pain. Exogenous EDPs 1 mg/kg combined with an ineffective low dose of t-TUCB 1 mg/kg to block their rapid degradation by the sEH enzyme were significantly effective against neuropathic pain (t-TUCB 1 mg/kg alone appears in supplemental material). In the CPP assay this is indicated by increased time (seconds, y axis) spent in the drug paired chamber (One Way ANOVA, p= 0.041). Prior to the CPP assay diabetic mice were assessed for phenotypic allodynia indicating diabetic neuropathy in the von Frey assay. The results depicted below the graph are the grams of force to elicit a hind paw withdrawal (von Frey (gr)) of pre-streptozocin baseline scores (Naïve) and post streptozocin painful baseline scores (Diabetic) prior to the start of treatment in the CPP assay.