Figure 1.
Current Model for Vesicle Dynamics at the Membrane
(A) Stylized cartoon showing a model for vesicle dynamics at the plasma membrane, where LDCVs are docked on molecular machinery depots. This is illustrated as a “well,” attracting LDCVs.
(B) Images from a TIRFM recording of a PC12 cell expressing lumenal NPY-EGFP. A single vesicle (gray sphere) is shown (track in color) scanning the membrane, visiting areas preferred by other vesicles (gray tracks). Grid scale, 500 nm grid edge. Color bar shows time.