Figure 14.

Schematic of “drug-free” therapeutics using polymer-coiled coil conjugates. The cell surfaces of human Burkitt′s NHL B cells were decorated with one half of a coiled coil binding partner (CCE peptide) by binding a CCE peptide/antiCD20 Fab' conjugate to cell-surface CD20. Subsequent binding with HPMA copolymers presenting complementary CCK coils led to cross-linking of the CD20 receptors and subsequent apoptosis. Reproduced from Ref 78 with permission, Copyright 2010, Wiley.