Figure 6. LTP stimulus occludes AMPA receptor functional incorporation.
A. Shown are mEPSC recordings from primary hippocampal neurons expressing CRY2-homer1c and GluA1-mCh-CIB. Traces are from the same cells in darkness and 6 min following blue light exposure for a control cell (top traces) and a cell pre-treated with cLTP stimulus (bottom traces). Scale bar 20pA, 1 sec.
B. cLTP occludes light triggered changes in mEPSC frequency (control dark vs. light, p<0.001 paired Student’s t-test, n=13 neurons; cLTP dark vs. light p=0.55, paired Student’s t-test, n=12 neurons). See also Fig. S3.